Synthesis of new 4(3H)-quinazolinone derivatives using 5(4H)-oxazolones.
نویسندگان
چکیده
New derivatives of 5(4H)-quinazolinone containing 2-imidazolin-5-one rings have been prepared from 5(4H)-oxazolone derivatives.
منابع مشابه
Thiamine hydrochloride (vitamin B1) as an efficient catalyst for the synthesis of 4-(3H)-Quinazolinone derivatives using grinding method.
Herein we explore facile synthesis of 4-(3H)-Qunazolinone derivatives, achieved by the cyclocondensation of anthranilic acid, aromatic amines and triethyl orthoformate in presence of thiamine hydrochloride (Vitamin B1) as a catalyst, using grinding method. This protocol offers several advantages such as reusability of catalyst, excellent yield, shorter reaction time and economic availability.Qu...
متن کاملThiamine hydrochloride (vitamin B1) as an efficient catalyst for the synthesis of 4-(3H)-Quinazolinone derivatives using grinding method.
Herein we explore facile synthesis of 4-(3H)-Qunazolinone derivatives, achieved by the cyclocondensation of anthranilic acid, aromatic amines and triethyl orthoformate in presence of thiamine hydrochloride (Vitamin B1) as a catalyst, using grinding method. This protocol offers several advantages such as reusability of catalyst, excellent yield, shorter reaction time and economic availability.Qu...
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We have developed a new method to prepare 4-acetoxy substituted 5(4H)-oxazolones by direct oxidation of N-benzoyl amino-acids using hypervalent iodine. The method is efficient, economical and easy to perform for the synthesis of quaternary substituted amino acid derivatives. We used online FTIR monitoring techniques to analyze the reaction, and gave a plausible reaction mechanism.
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Quinazolinones are interesting molecules with a wide range of biological activities. We prepared a number of quinazolinone derivatives by the condensation of 5-bromo- or 5-nitro-substituted anthranilic acids with chloro-acyl chlorides. Anthranilic acid derivatives were treated with either 3-chloro-propionyl chloride or 4-chloro-butyryl chloride to yield the corresponding N-acyl-anthranilic acid...
متن کاملJul - Aug 2006 Convenient Synthesis of Some 1057 2 - Substituted 4 ( 3 H ) - Quinazolinone Derivatives
4(3H)-Quinazolinones 1 are known for more than a century [1]. Molecules based on quinazoline and quinazolinone exhibit a multitude of interesting pharmacological activities [2], including anticonvulsant, antibacterial and antidiabetic activity [3,4]. The important natural and synthetic 4(3H)-quinazolinones include l-vasicinone 2 [5], chrysogine 3 [6], methaquinalon 4 [7] – a sedative, piriqualo...
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ورودعنوان ژورنال:
- Molecules
دوره 11 5 شماره
صفحات -
تاریخ انتشار 2006